Interactions | Reactions | Processes


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Classified as: Benzyne Mechanism



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The benzyne mechanism is a type of strong base catalysed elimination-followed-by-addition aromatic substitution. A strong base, often NH2- in NH3, abstracts a proton which initiates the ejection of a nucleofuge so forming a highly reactive "benzyne", a type of highly strained alkyne. The benzyne reactive intermediate is highly susceptible to nucleophilic addition. Benzyne reaction products show characteristic substitution patterns.
        
  +  
CO2
  +  
CO

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  +  
RLi
        
  +  
LiF
  +  
R–H

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  +  
N2
  +  
CO2

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  +  
        
  +  
Li+
  +  
F–

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© Mark R. Leach 1999 –

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